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December 8, 2025BloodOpen Access

Spatial transcriptomic dissection of the myeloproliferative neoplasm niche uncovers mutant clone interactions and microenvironmental rewiring

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Authors

HBHonghao BiLSLaya SoleimaniPJPeng Ji

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Overview

Spatial transcriptomics reveals gene expression changes in myeloproliferative neoplasms, indicating distinct microenvironment interactions.

Key Points

  • To explore the interactions of mutant clones within the bone marrow niche of myeloproliferative neoplasms.
  • Utilized spatial transcriptomics on bone marrow samples from patients with myeloproliferative neoplasms.
  • Employed Xenium high-plex panel and Visium HD analyses on matched samples.
  • Conducted Robust Cell Type Decomposition for cell type annotation.
  • Identified distinct clustering of JAK2 and TET2 mutant cells in the bone marrow niche.
  • Gene expression analysis revealed elevated levels of specific genes in neighboring cells around JAK2 mutants.
  • Niche analysis indicated preferential localization of JAK2-mutant cells in erythroid-rich niches.

Cite This Study

Bi et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d13bhttps://doi.org/10.1182/blood-2025-3761
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