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December 8, 2025BloodOpen Access

Replication fork remodeling is a therapeutic vulnerability in acute myeloid leukemia

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Authors

TFTsz Kan FungTGTristan GasparettoCSChi Wai Eric So

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Overview

Research reveals DNA damage response dynamics in AML, highlighting PARP inhibitors as potential therapeutic targets.

Key Points

  • To investigate the role of replication fork remodeling in acute myeloid leukemia (AML) and its therapeutic implications.
  • Examined DNA replication dynamics in human and mouse AML models with different oncofusion proteins
  • Utilized single-cell assays, comet assays, and quantitative image-based cytometry under treatment conditions
  • Combined functional assays with replication fork plasticity factor manipulations to assess therapy response
  • AML lines show accelerated replication fork progression compared to control cells
  • PARP inhibitors increase DNA damage in specific AML types by promoting fork breakage
  • Initial findings suggest fork plasticity factors can serve as therapeutic targets for AML treatment

Cite This Study

Fung et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d10bhttps://doi.org/10.1182/blood-2025-5016
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