Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Dietary serine restriction increases venetoclax efficacy in Acute Myeloid Leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

MBMichael J. Betenbaugh

Discussion

Loading...

Member takes

Overview

Experimental findings show dietary serine deprivation sensitizes AML cells to venetoclax, suggesting metabolic strategies for treatment.

Key Points

  • This research aims to investigate the role of dietary serine restriction in enhancing the efficacy of venetoclax in treating Acute Myeloid Leukemia (AML).
  • Examined the impact of serine depletion on AML cell lines (MV4-11, MOLM-13, NOMO-1, THP-1) cultured in serine-free media.
  • Measured proliferation rates and analyzed serine synthesis pathway enzyme expression, particularly PHGDH.
  • Performed mass spectrometry isotope tracing to assess metabolic flux and ATP levels under different conditions.
  • Used xenograft models to evaluate treatment effects in mice fed serine/glycine-free diets alongside venetoclax.
  • Serine depletion reduced proliferation rates of AML cells, indicating sensitivity.
  • Isotope tracing revealed that venetoclax impaired metabolic flux in serine synthesis pathways.
  • Serine deprivation lowered the IC50 for venetoclax, indicating increased efficacy.
  • In vivo experiments showed that mice on a serine/glycine-free diet exhibited delayed AML progression and improved survival rate.

Cite This Study

Michael J. Betenbaugh (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0e5https://doi.org/10.1182/blood-2025-5046
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell transcriptomic insights into venetoclax response and resistance in secondary AML evolving from MDS2025
  2. 2LSD1 inhibition enhances venetoclax efficacy in Acute Myeloid Leukemia via metabolic rewiring2025
  3. 3<scp>BCL</scp>‐2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in <scp>AML</scp>2025 · 4 citations
  4. 4Venetoclax and hypomethylating agents synergize to increase cell death and metabolic remodeling in acute B-lymphoblastic leukemia cells2026
  5. 5Single-cell insights into acute myeloid leukemia treated with venetoclax-based therapy2025