Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Mutational architecture and clonal heterogeneity in myelofibrosis: Prognostic role of variant type and acquisition sequence

View Full Paper
Ask AI
Bookmark
Share

Authors

PGPaola Guglielmelli

Discussion

Loading...

Member takes

Overview

Analysis reveals somatic mutations, including dnmt3a, impact overall survival in myelofibrosis, suggesting a prognostic role for mutation type.

Key Points

  • Evaluating how specific somatic mutations influence clinical outcomes in myelofibrosis patients.
  • Analyzed 756 patients with myelofibrosis using a 40-gene NGS panel at diagnosis.
  • Classified mutations into functional categories and compared variant allele frequencies.
  • Investigated mutation orders and their associations with clinical outcomes.
  • 62% of patients diagnosed with primary MF and 38% with secondary MF; overall survival median was 6.2 years.
  • Somatic mutations like dnmt3a were observed, affecting prognosis and survival.
  • Significant associations between mutation types and shorter overall survival were identified.

Cite This Study

Paola Guglielmelli (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0cfhttps://doi.org/10.1182/blood-2025-3760
View Full Paper
Ask AI
Bookmark
Share