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December 8, 2025BloodOpen Access

Head-to-head longitudinal comparison of two mass spectrometry-based methods for monitoring monoclonal proteins in multiple myeloma: Analytical and clinical insights from the GEM-CESAR trial

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Authors

RRRafael RíosCPChai W. PhuaSLSunil Lakhwani

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Overview

Longitudinal analysis of mass spectrometry detects monoclonal proteins in multiple myeloma, highlighting clinical implications for disease monitoring.

Key Points

  • This research aims to compare the analytical performance of two mass spectrometry methods for monitoring monoclonal proteins in multiple myeloma.
  • Analyzed 55 serum samples from 18 patients with high-risk smoldering multiple myeloma.
  • Compared MALDI-TOF and LC-Q/TOF for sensitivity and concordance in detection of monoclonal proteins.
  • Assessed measurable residual disease in bone marrow using next-generation flow following IMWG recommendations.
  • 72.7% of paired serum samples showed concordant results between both methods.
  • LC-Q/TOF detected more positive samples than MALDI-TOF.
  • Progression-free survival was significantly stratified by both techniques, especially at M2.

Cite This Study

Ríos et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0c2https://doi.org/10.1182/blood-2025-2238
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