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December 8, 2025BloodOpen Access

Aplastic anemia treatment in older adults in resource-limited settings: Can rabbit ATG bridge the gap?

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Authors

DCDavid Solar CafaggiYGY GarcíaLJLeire Montoya Jiménez

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Overview

Multicenter study shows rabbit ATG linked to lower overall response rates in older adults with aplastic anemia, suggesting alternative strategies may be needed.

Key Points

  • To evaluate the effectiveness of rabbit ATG in improving overall response rates in patients aged 60 and older with aplastic anemia.
  • Conducted a multicenter study in five referral centers in Mexico.
  • Defined three treatment groups: rabbit ATG plus immunosuppressive therapy, CsA/ETB, and other treatments.
  • Assessed overall response and survival rates at multiple time points after treatment initiation.
  • Higher overall response rates were noted for CsA/ETB compared to rabbit ATG.
  • At 12 months, response rates were CsA/ETB 81.2%, rabbit ATG 35.3%, and other therapies 40.5%.
  • Overall survival was better for CsA/ETB at 36 months compared to rabbit ATG, indicating poor outcomes with rabbit ATG use.

Cite This Study

Cafaggi et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d089https://doi.org/10.1182/blood-2025-1095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical outcomes of frontline ATG-based immunosuppressive therapy in older patients with aplastic anemia2025
  2. 2Prognostic consequences of delayed treatment in severe aplastic anemia: A challenge in resource-constrained healthcare systems2025
  3. 3Anti-thymocyte globulin-based treatment frequently leads to enduring treatment success in both old and young adult patients with aplastic anaemia: a real-world analysis from the Dutch aplastic anaemia registry2026
  4. 4Thrombopoietin receptor agonists combined with intensive immunosuppressive therapy improve outcomes in elderly patients with severe aplastic anemia: A single-center retrospective study2025
  5. 5A meta-analysis of immunosuppressive and Pharmacological therapies in aplastic anaemia with and without Indigenous equine antithymocyte globulin (eATG)2026 · 6 citations