Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 8, 2025BloodOpen Access

Evaluating the effect of morbid obesity on DVT in patients already on doac therapy: A retrospective analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

HHHashim Talib HashimFZFarigol Hakem ZadehAMAseed Mestarihi

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows morbid obesity does not increase DVT recurrence or mortality in VTE patients, indicating DOAC safety.

Key Points

  • This study assesses the relationship between morbid obesity and adverse outcomes in patients with VTE receiving DOAC therapy.
  • Retrospective cohort study of 1,562 patients diagnosed with VTE on DOACs.
  • Patients stratified by obesity status defined as BMI > 40.
  • Logistic regression evaluated obesity's association with bleeding events and mortality.
  • Negative binomial regression assessed predictors of hospital length of stay.
  • 13.0% of patients classified as obese.
  • Obesity not significantly associated with bleeding events (OR = 1.404, p = 0.2572) or mortality (OR = 0.879, p = 0.7299).
  • Obesity did not significantly influence hospital length of stay (IRR = 1.037, p = 0.6616).
  • Predictors of mortality included older age, male sex, and hypercoagulable state.

Cite This Study

Hashim et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d07ehttps://doi.org/10.1182/blood-2025-3122
View Full Paper
Ask AI
Bookmark
Share