December 8, 2025Blood

Real-World Effectiveness and Resource Utilization of Red Blood Cell Exchange in Adult Sickle Cell Disease: a Nationwide Robust Analysis from 2017-2022

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To evaluate the real-world effectiveness and resource utilization of red blood cell exchange in adults with sickle cell disease.
Conducted a retrospective cohort study using Healthcare Cost and Utilization Project data from 2017 to 2022.
Included hospitalized adults with sickle cell disease based on ICD-10-CM codes.
Employed multivariable logistic regression to calculate propensity scores and applied inverse probability of treatment weights for analysis.
Analyzed mortality outcomes with penalized logistic regression and resource use with survey-weighted models.
The study included 185,332 adult hospitalizations for sickle cell disease.
RBC exchange was performed in 2,775 cases, representing infrequent use of the therapy.
Patients receiving RBC exchange had longer hospital stays and higher total charges, with significant increases in resource utilization.
No significant association was found between RBC exchange and in-hospital mortality after adjustment.

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Implication

Retrospective cohort study shows RBC exchange increases resource utilization in adults with sickle cell disease, indicating a need for informed clinical guidelines.

Cite This Study

Amalraj et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d03a https://doi.org/10.1182/blood-2025-7968

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Implication

Retrospective cohort study shows RBC exchange increases resource utilization in adults with sickle cell disease, indicating a need for informed clinical guidelines.

Real-World Effectiveness and Resource Utilization of Red Blood Cell Exchange in Adult Sickle Cell Disease: a Nationwide Robust Analysis from 2017-2022

Key Points

Discussion

Implication

Cite This Study

Real-World Effectiveness and Resource Utilization of Red Blood Cell Exchange in Adult Sickle Cell Disease: a Nationwide Robust Analysis from 2017-2022

Key Points

Discussion

Implication

Cite This Study

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