What question did this study set out to answer?

To evaluate the impact of pre-transplant depression and anxiety on outcomes of AML patients after allogeneic stem cell transplantation.

December 8, 2025Blood

Impact of pre-transplant anxiety and depression on outcomes of AML patients after allogeneic transplantation

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Authors

NANeda AmirmokhtariThe University of Kansas Health System

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Implication

Retrospective study reveals no significant impact of pre-transplant depression and anxiety on overall survival in AML patients undergoing allogeneic transplantation, suggesting supportive care is key.

Key Points

To evaluate the impact of pre-transplant depression and anxiety on outcomes of AML patients after allogeneic stem cell transplantation.
Retrospective review of 115 adult AML patients post allo-SCT at University of Kansas Medical Center (2022-2024)
Psychology-oncology team conducted pre-transplant evaluations including PHQ-9, GAD-7, and MoCA assessments
Survival outcomes analyzed using Kaplan-Meier model and log-rank test
Median overall survival was 72% and progression free survival was 67% over 3 years
No significant association between severity of depression, anxiety, cognitive function, and overall survival or progression free survival
Significant association found between severity of depression and incidence of acute graft versus host disease

Cite This Study

Neda Amirmokhtari (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf87 https://doi.org/10.1182/blood-2025-2851

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Impact of pre-transplant anxiety and depression on outcomes of AML patients after allogeneic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of pre-transplant anxiety and depression on outcomes of AML patients after allogeneic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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