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This research aims to assess the diagnostic value of the DLB-related pattern (DLBRP) across different disease stages of dementia with Lewy bodies.

Metabolic brain networks in dementia with Lewy bodies: from prodromal to manifest disease stages

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Evaluation of DLBRP as a metabolic biomarker improves DLB diagnosis in all disease stages, suggesting clinical implications.

This research aims to assess the diagnostic value of the DLB-related pattern (DLBRP) across different disease stages of dementia with Lewy bodies.
Analyzed demographic, clinical, and FDG PET imaging data from 1180 participants across 14 tertiary centers and two datasets.
Included 379 DLB, 28 MCI-LB, 195 ADD, 172 MCI-AD-S-, and 73 MCI-AD-S+ patients, with 333 normal controls for comparison.
Calculated DLBRP, ADRP, and PDRP expression from scans and compared across groups.
DLBRP distinguished DLB from NCs with sensitivity >89% and specificity >90%.
Scores of DLBRP correlated with clinical measurements, particularly the Unified Parkinson’s Disease Rating Scale Part III.
DLBRP scores increased prior to dementia onset in a longitudinal dataset, indicating early diagnostic potential.

Kramberger et al. (2025) studied this question.

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