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December 8, 2025DiseasesOpen Access

Colorectal Cancer in the U.S., 1999–2021: Declining Rates, Rising Concerns, and Persistent Disparities

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Authors

QGQais Bin Abdul GhaffarSNSeemab Naqvi

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Overview

Retrospective analysis reveals declining colorectal cancer rates in the U.S., indicating persistent disparities in mortality.

Key Points

  • This research aims to analyze trends in colorectal cancer incidence and mortality rates in the U.S. from 1999 to 2021.
  • Utilized de-identified data from CDC WONDER United States Cancer Statistics database
  • Examined incident colorectal cancer cases and deaths using SEER and ICD-10 codes
  • Calculated age-adjusted rates and mortality-to-incidence ratios using Stata 17.0
  • Employed Joinpoint regression to identify trends in rates.
  • Colorectal cancer incidence decreased from 78.24 (1999) to 50.79 (2021) with an AAPC of −2.20%
  • Mortality rates decreased from 29.34 to 17.92 with an AAPC of −2.33%
  • Young adults showed an increase in incidence and mortality but improving mortality-to-incidence ratios
  • Non-Hispanic Black individuals had the highest mortality-to-incidence ratio (0.400 in 2021)

Cite This Study

Ghaffar et al. (2025) studied this question.

synapsesocial.com/papers/693624c34fa91c937236cc9chttps://doi.org/10.3390/diseases13120392
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