Exploratory analysis shows anosognosia predicts faster onset of apathy and motor symptoms in Alzheimer's patients, suggesting tailored interventions may improve outcomes.
Key Points
The aim is to explore the relationship between anosognosia and neuropsychiatric symptoms in Alzheimer’s disease dementia patients.
Compared prevalence of neuropsychiatric symptoms in patients with and without anosognosia.
Examined associations using Cox proportional hazards models.
Included patients with baseline assessments and follow-up evaluations with specific cognitive measures.
47.3% of patients exhibited anosognosia at baseline.
Patients with anosognosia had a trend towards more agitation and motor symptoms.
A faster onset of apathy was found in patients with anosognosia, with a hazard ratio of 2.78 (p = 0.01).