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December 8, 2025Pharmacognosy MagazineOpen Access

Hepatoprotective and Anti-oxidant Effects of Osajin in Acetaminophen-induced Hepatotoxicity in Rats

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QWQiaolin Wang

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Overview

Study demonstrates hepatoprotective impact of osajin on liver injury in rats, indicating its antioxidant potential.

Key Points

  • To evaluate the hepatoprotective effects of osajin against acetaminophen-induced liver injury in rats.
  • Divided 24 rats into four groups: control, APAP control, APAP + silymarin, and APAP + osajin.
  • Administered treatments and measured serum biomarkers and hematological parameters.
  • Assessed oxidative stress by analyzing protein carbonyl levels and anti-oxidant enzyme activity.
  • Performed histopathological examinations to evaluate liver damage.
  • OSJ significantly reduced alanine transaminase, aspartate aminotransferase, and lactate dehydrogenase levels.
  • Restored hematological parameters and lipid homeostasis, reducing triglycerides.
  • Enhanced antioxidant enzyme activity alleviated oxidative stress associated with liver injury.
  • Histopathological analysis confirmed reduced inflammation and preserved hepatic architecture.

Cite This Study

Qiaolin Wang (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c705https://doi.org/10.1177/09731296251391924
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