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December 8, 2025Journal of Viral HepatitisOpen Access

Immune Checkpoints Determine the NK / NKT and T Cell Immunity in Chronic Hepatitis B

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Authors

YGYurong GuLGLin GuYHYuehua Huang

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Overview

Analyses reveal immune checkpoint roles affecting T cell function in chronic hepatitis B, suggesting therapeutic targets.

Key Points

  • This research aims to evaluate the role of immune checkpoints in regulating immune responses in chronic hepatitis B.
  • Analyzed clinical and immune data from 334 chronic hepatitis B patients and 17 healthy controls.
  • Assessed immune cell profiles using flow cytometry.
  • Examined immune checkpoints expression on innate and adaptive immune cells across different disease stages.
  • Identified distinct immune profiles and varying immune checkpoints expression in patients at different stages of chronic hepatitis B.
  • Found associations between immune checkpoints levels and immune cell functions, including cytotoxicity and cytokine production.
  • Demonstrated interactions between NK/NKT cells and T cell functionality through immune checkpoints.

Cite This Study

Gu et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c5f9https://doi.org/10.1111/jvh.70108
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  1. 1Altered NK Cell Phenotype in Tenofovir-Treated Chronic Hepatitis B Patients and Identification of Genes Regulating the mTOR Pathway 92032025
  2. 2Single‐Cell Profiling of Peripheral and Intrahepatic B Cells Reveals Altered Responses and a CCR7⁺ Subset Linked to Antiviral Potential in Chronic HBV Infection2025 · 1 citations
  3. 3Immunopathology of Chronic Hepatitis B2025
  4. 4Immune checkpoint biology in hepatocellular carcinoma (Review)2025 · 5 citations
  5. 5Clinical cure of chronic hepatitis B is dependent on activation and perpetuation of robust CD4+ T cell responses2025