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December 8, 2025Journal of Cellular PhysiologyOpen Access

Telomere Attrition‐Induced Senescence in Human Pluripotent Stem Cell‐Derived Astrocytes: Distinct Cellular and Functional Characteristics

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Authors

SOSeung Soo OhGYGyu‐Bum YeonJCJae‐Yeon Choi

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Overview

Pharmacological inhibition of telomerase activity induces senescence in astrocytes, revealing limited functional impairment, suggesting complex cellular stress pathways.

Key Points

  • This research examines the impact of telomere attrition on senescence in human pluripotent stem cell-derived astrocytes.
  • Inhibition of telomerase using BIBR1532 during differentiation of astrocytes
  • Assessment of senescence markers including β-galactosidase activity and nuclear lamina abnormalities
  • Evaluation of functional astrocytic properties like glutamate uptake and mitochondrial membrane potential
  • Inhibition led to increased nuclear lamina abnormalities and dna damage
  • Limited changes in senescence-associated secretory phenotype-related genes were observed
  • BIBR-treated astrocytes maintained key functional properties comparable to controls

Cite This Study

Oh et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c331https://doi.org/10.1002/jcp.70118
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