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December 8, 2025npj Antimicrobials and ResistanceOpen Access

Evolution of proteolysis-targeting chimeras (PROTAC) technology to overcome challenges of antimicrobial resistance

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Authors

DSDhanashree N. SarwanPKPramod KhedekarRCRupesh V. Chikhale

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Overview

This review examines PROTAC evolution and its impact on drug resistance in microorganisms, highlighting delivery via nanoparticles and exosomes.

Key Points

  • The review aims to explore the development and application of PROTAC technology in overcoming antimicrobial resistance.
  • Review of PROTAC technology
  • Discussion on linker design and E3 ligase selection
  • Exploration of delivery methods including nanoparticles and exosomes
  • Highlighting the evolution of PROTACs
  • Discussing advancements related to antimicrobial resistance
  • Noting the significance of innovative delivery methods like nanoparticles and exosomes

Cite This Study

Sarwan et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c2eahttps://doi.org/10.1038/s44259-025-00136-w
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