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This study examines the relationship between CHI3L1 expression, APOE ε4 status, and early-onset Alzheimer's disease.

Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

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Analysis shows elevated CHI3L1 in early-onset Alzheimer's, highlighting genetic risk factors and immune activity in peripheral blood.

This study examines the relationship between CHI3L1 expression, APOE ε4 status, and early-onset Alzheimer's disease.
Analyzed mRNA expression of CHI3L1 in peripheral blood samples from individuals with AD, MCI, and healthy controls.
Compared CHI3L1 levels across diagnostic groups and stratified by APOE ε4 status, age, and sex.
Examined correlations between CHI3L1 and inflammatory gene transcripts including IL1B and LRP1.
Elevated CHI3L1 in early-onset Alzheimer's, especially in APOE ε4 carriers (p = 0.026).
Correlation observed between CHI3L1 levels and transcripts of inflammatory genes, notably in APOE ε4 + individuals.
Findings suggest early immune activation trends in individuals at risk of neurodegeneration.

Lina Breit (2025) studied this question.

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