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December 8, 2025Frontiers in Cardiovascular MedicineOpen Access

Left ventricular hypertrophy and myocardial work in amateur marathon runners

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Authors

JWJun-cheng WangHTHai-Yan TianQZQinghong Zeng

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Overview

Amateur marathon runners exhibit left ventricular hypertrophy, reducing myocardial work efficiency, suggesting running distance influences outcomes.

Key Points

  • This research aims to assess the relationship between left ventricular hypertrophy and myocardial work in amateur marathon runners.
  • Categorized amateur marathon runners into LVH and non-LVH groups based on guidelines.
  • Compared myocardial work outcomes with a healthy control group without exercise habits.
  • Calculated global work index, global constructive work, global work efficiency, and global wasted work using pressure-strain loop methodology.
  • Applied regression analysis to evaluate factors influencing LVH in male runners.
  • Non-LVH and LVH groups had significant left atrium and left ventricle enlargement compared to controls.
  • LVH group showed lower global work efficiency and global wasted work than non-LVH group.
  • Weekly running distance associated with increased odds of LVH (OR = 1.97, CI: 1.37–3.48).
  • Negative correlation found between weekly running distance and global work efficiency (r = -0.37, P = 0.002).

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c205https://doi.org/10.3389/fcvm.2025.1707542
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