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December 6, 2025BMJ Public HealthOpen Access

Mixed-methods study assessing the acceptability and feasibility of Human Challenge Studies for Disease X in Healthy UK Adults in a SARS-CoV-2 pandemic setting

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Authors

MPMaia Patrick-SmithTTTonia M. ThomasNDNaomi Douglas

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Overview

Mixed-methods study finds willingness to participate in SARS-CoV-2 challenge studies among younger adults, highlighting potential effectiveness in recruitment strategies.

Key Points

  • Approximately 45% of invited individuals completed the survey, demonstrating significant engagement in assessing CHIS acceptability.
  • Motivations for participation in SARS-CoV-2 challenge studies included altruism and the urgency of public health needs.
  • Mixed-methods study conducted in Oxford, UK, utilized surveys and interviews to assess participant views.
  • Findings suggest targeting recruitment at younger, single individuals may enhance enrollment in pandemic-related studies.

Cite This Study

Patrick-Smith et al. (2025) studied this question.

synapsesocial.com/papers/69337d02b3f947a0a125a9c8https://doi.org/10.1136/bmjph-2025-003096
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