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December 6, 2025Frontiers in ImmunologyOpen Access

Identification of MUC5B as a lymph node metastasis-associated gene in lung adenocarcinoma through integrated transcriptomic and machine learning approaches

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Authors

MDMinjun DuYGYushun Gao

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Overview

Analysis reveals MUC5B's role as a biomarker for lymph node metastasis in lung adenocarcinoma, suggesting therapeutic potential.

Key Points

  • MUC5B serves as a critical biomarker influencing lymph node metastasis in lung adenocarcinoma.
  • The predictive model demonstrated high accuracy for metastasis identification, with an AUC greater than 0.9.
  • Transcriptional and immunohistochemical analyses confirmed MUC5B upregulation in metastatic cases, linking it to tumor progression.
  • Findings highlight a potential regulatory role of MUC5B in invasion and cell cycle processes within LUAD.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/69337cceb3f947a0a1259c7fhttps://doi.org/10.3389/fimmu.2025.1666240
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