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December 6, 2025npj Metabolic Health and DiseaseOpen Access

Central cytometabolic functional vascular coupling in health and disease

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Authors

SSStuart SimsBWBlaine E. WeissRLRuei‐Lung Lin

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Overview

Review highlights cell interaction in the neurovascular unit, showing how astrocytes and neurotransmitters maintain homeostasis in health and disease.

Key Points

  • Functional hyperemia response was examined within the neurovascular unit, which includes intercellular communications among diverse cell types.
  • Key findings cover the role of astrocytes and neurotransmitters in sustaining homeostasis across various health and disease states.
  • This review analyzes the involvement of signaling molecules and modulator mechanisms in maintaining vascular coupling.
  • Understanding these dynamics could provide insights into therapies for diseases affecting the neurovascular unit.

Cite This Study

Sims et al. (2025) studied this question.

synapsesocial.com/papers/69337cceb3f947a0a1259bf1https://doi.org/10.1038/s44324-025-00090-1
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