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December 5, 2025Cancer Research CommunicationsOpen Access

Copy number aberrations in circulating tumor DNA enable diagnosis and risk stratification of pediatric neuroblastic tumors

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Authors

TTTing TaoJCJiabin CaiYTYinbing Tang

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Overview

Analysis reveals that circulating tumor DNA can reliably diagnose neuroblastoma and ganglioneuroblastoma, indicating its potential for risk stratification in pediatric patients.

Key Points

  • Circulating tumor DNA effectively identifies high-risk pediatric neuroblastic tumors, enhancing diagnosis.
  • The area under curve for predicting high-risk neuroblastic tumors reached 0.95, with 94.12% sensitivity.
  • Low-pass whole-genome sequencing provides critical insights into chromosomal copy number changes in tumors.
  • Highlights the importance of liquid biopsy techniques in pediatric cancer diagnostics and treatment monitoring.

Cite This Study

Tao et al. (2025) studied this question.

synapsesocial.com/papers/693231308e51979591dce9b7https://doi.org/10.1158/2767-9764.crc-25-0452
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