Anthelminthic Activity of Piper nigrum , Albizia ferruginea , and Guarea cedrata Against Caenorhabditis elegans and Heligmosomoides polygyrus : In Vitro and In Silico Molecular Docking Approach
In vitro evaluation reveals deworming potential of Piper nigrum and Albizia ferruginea against Heligmosomoides polygyrus, suggesting their traditional medicinal use.
Key Points
The ethanolic extract of Piper nigrum showed significant anthelmintic activity with an IC50 of 0.04 mg/mL against Heligmosomoides polygyrus.
Aqueous extracts of Albizia ferruginea and Piper nigrum exhibited potent activity, with IC50s of 3.235 and 7.850 μg/mL, respectively, against larvae.
Molecular docking analysis was utilized to assess the binding of extracts to succinate dehydrogenase and β‐tubulin in nematodes.
These findings support the traditional use of these plants for helminth infections, but further investigations are necessary for validation.