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December 4, 2025LifeOpen Access

Beyond HOMA-IR: Comparative Evaluation of Insulin Resistance and Anthropometric Indices Across Prediabetes and Type 2 Diabetes Mellitus in Metabolic Syndrome Patients

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Authors

MAMohamed-Zakaria AssaniLBLidia BoldeanuADAnda Lorena Dijmărescu

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Overview

Cross-sectional analysis shows higher insulin resistance in type 2 diabetes compared to prediabetes, indicating alternative indices may offer better risk stratification.

Key Points

  • Type 2 diabetes was associated with higher insulin resistance compared to prediabetes, with lipid ratios performing well.
  • Body mass index (BMI) remained similar between prediabetes and type 2 diabetes patients despite differences in glycemic indices.
  • In regression models, metabolic syndrome characteristics like anthropometric indices best explained insulin resistance.
  • Alternative indices like METS-IR and TyG may enhance insulin resistance assessment in metabolic syndrome patients without insulin tests.

Cite This Study

Assani et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3a3ehttps://doi.org/10.3390/life15121845
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  1. 1Global Burden of Cardiovascular Diseases and Risk Factors, 1990–20192020 · 11,659 citations