December 4, 2025MedicineOpen Access

Association between nitrogen oxides and COVID-19 risk: A Mendelian randomization study

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Mendelian randomization reveals association between nitrogen oxides and COVID-19 risk, suggesting air pollution impacts health.

COVID-19 risk increased with nitrogen oxides air pollution exposure, notably in hospitalized individuals.
The odds ratio for COVID-19 associated with NOx exposure was 3.76, indicating a significant risk increase.
Analysis employed Mendelian randomization methods and utilized integrated data from genome-wide association studies.
Findings suggest potential causation between nitrogen dioxide and COVID-19 risk, emphasizing air pollution control.

Chen et al. (2025) studied this question.

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