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December 4, 2025EMBO Molecular MedicineOpen Access

Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever

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Authors

JSJoel B. SheffieldMEMohamed ElGhazalyDODaniel O’Connor

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Overview

Observational analysis shows that Salmonella infection induces p53-mediated responses, indicating its role in reducing oxidative DNA damage.

Key Points

  • Inhibition of oxidative DNA damage occurs during Salmonella infection, highlighting the role of p53.
  • Quantitative proteomic analysis revealed elevated levels of apolipoprotein C3 in participants with typhoid fever.
  • Observational analysis identifies the relationship between DNA damage responses and antimicrobial responses during typhoid.
  • These findings suggest that targeting Salmonealla infection may enhance interventions against typhoid fever.

Cite This Study

Sheffield et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2a82https://doi.org/10.1038/s44321-025-00347-8
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