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December 4, 2025Molecular Systems BiologyOpen Access

Expansion omics: from expansion microscopy to spatial omics

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Authors

ZDZhen DongTGTiannan Guo

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Overview

Perspective reveals integration of spatial omics and tissue expansion, highlighting improved biomolecule detection and mapping.

Key Points

  • Expansion omics enables precise detection of biomolecules, enhancing spatial resolution from subcellular to sub-nanometer scales.
  • High-resolution mapping of chromatin states and gene expression offers critical insights into tissue biology and function.
  • Observational analysis across various spatial omics modalities showcases the versatility of tissue expansion techniques.
  • Challenges in molecular retention and data scalability highlight the need for ongoing improvements in expansion omics methodologies.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca292fhttps://doi.org/10.1038/s44320-025-00171-9
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