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This is a Meta-Analysis study (also classified as: Systematic Review).

The Pleiotropic Influence of Cannabidiol and Tetrahydrocannabinol on Inflammatory Biomarkers: A Systematic Review and Meta-Analytical Synthesis

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Inconsistent effects of CBD and THC on inflammatory biomarkers were noted, with minimal impacts reported.
Meta-analyses showed mean differences for IL-6 with a standardized mean difference of −0.17 and a p-value of 0.41.
Systematic review and random-effects meta-analysis were employed, assessing 13 studies for clinical translation.
Current findings highlight the trivial efficacy of phytocannabinoids, reinforcing the need for more rigorous clinical studies.

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Systematic review reveals minor effects on IL-6 in inflammatory pathways, suggesting THC and CBD may have limited clinical impact.

Oliveira et al. (2025) studied this question.

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