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December 4, 2025Biotechnology and Applied Biochemistry

Virtual Screening and Molecular Dynamics Studies of Phytochemicals Targeting Ran GTPase: Identification of Potential Inhibitors

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Authors

ANAmka NagarHPHitesh D. Patel

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Overview

Virtual screening identifies natural compounds with strong binding affinity in targeting Ran GTPase, suggesting viability for cancer therapy.

Key Points

  • Natural compounds demonstrate a strong binding affinity toward Ran GTPase, indicating potential therapeutic value.
  • Binding scores from molecular docking ranged from –13.85 to –10.48 kcal/mol, suggesting strong interactions at the active site.
  • Virtual screening and molecular docking employed for exploring phytochemicals from the SuperNatural database targeting Ran GTPase.
  • These findings highlight potential entry points for developing new therapeutic agents against breast cancer and similar malignancies.

Cite This Study

Nagar et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca2322https://doi.org/10.1002/bab.70103
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