December 4, 2025Military Medical ResearchOpen Access

β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

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Peritoneal fibrosis is influenced by β-catenin signaling and senescent mesothelial cells.
Single-cell RNA sequencing showed significant changes in mesothelial cells from long-term PD patients.
The interplay of senolytic drugs and β-catenin represents a new therapeutic strategy against fibrosis.
Transforming growth factor-β activation correlates with myofibroblast activation in peritoneal biopsies.

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Analysis reveals β-catenin signaling and senolytic drugs reduce peritoneal fibrosis linked to mesothelial cell senescence.

Wang et al. (2025) studied this question.

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