Comprehensive UHPLC‐ESI‐Orbitrap‐MS Profiling and Bioactivity‐Guided Fractionation of Euphorbia greenwayi : Mechanistic Insights Into Anti‐Inflammatory and Antiaging Bioactive Metabolites
Analysis reveals bioactive metabolites in Euphorbia greenwayi with potent anti‐inflammatory effects, suggesting therapeutic potential for age‐related diseases.
Key Points
Fraction EG5 showed significant dose‐dependent inhibition of COX‐2 and other enzymes, confirming its anti‐inflammatory properties.
Bioactive metabolites, including tricin and xanthurenic acid, were identified through UHPLC‐ESI‐Orbitrap‐MS analysis.
Multivariate data analysis and clustering methods classified the phytochemical profile of Euphorbia greenwayi's main fractions effectively.
These findings highlight the therapeutic potential of bioactive metabolites in treating inflammation and age‐related conditions.