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December 4, 2025YAKUGAKU ZASSHIOpen Access

Analysis of Plastic Changes in Spinal Neurons in Fibromyalgia and the Exploration of Therapeutic Agents

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Analysis reveals altered nociceptive signaling and potential therapeutic agents in fibromyalgia, implying new treatment avenues.

Enhanced synaptic transmission contributes to pain sensitivity in fibromyalgia, indicating a disruption in spinal processing.
Increased ASIC3 expression and microglial activation were noted in dorsal root ganglia in fibromyalgia models.
Therapeutic agent minocycline effectively reduced mechanical hyperalgesia, highlighting its potential application.
Imbalances in sensory gating and nociceptive transmission suggest pivotal mechanisms underlying fibromyalgia's pathophysiology.

Daisuke Uta (2025) studied this question.

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