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November 30, 2025CancersOpen Access

MET Overexpression Is Associated with Superior Immunotherapy Benefit in Advanced Non-Small Cell Lung Cancer

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Authors

HLHui LiLHLingzhi HongPRPedro Rocha

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Overview

Retrospective analysis shows MET overexpression correlates with improved progression-free survival in NSCLC, suggesting its role as a prognostic factor for immune checkpoint inhibitors.

Key Points

  • MET overexpression significantly improves progression-free survival in advanced non-small cell lung cancer patients.
  • 78.9% of patients demonstrated MET overexpression, which correlates with positive immune checkpoint inhibitor response.
  • Assessment involved logistic regression and Kaplan–Meier analysis alongside Cox proportional hazards model for robust findings.
  • These findings highlight MET expression as a potential predictive biomarker for immunotherapy efficacy in NSCLC patients.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692b9d8d1d383f2b2a379947https://doi.org/10.3390/cancers17233801
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