November 30, 2025Frontiers in EndocrinologyOpen Access

Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes

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Study reveals protein carbonylation in β-cells contributes to dysfunction in type 1 and type 2 diabetes, highlighting oxidative stress implications.

Reduced functional β-cell mass is linked to oxidative stress and protein carbonylation in diabetes, and antioxidant enzymes may offer protection.
Increased lipid peroxidation and carbonylation observed in red blood cells and adipose tissue among patients with type 1 and type 2 diabetes.
Assessment of protein carbonylation's role in pancreatic islets suggests potential NRF2 activation benefits for β-cell preservation.
Understanding carbonylation's impact on β-cell function may inform approaches for better diabetes management.

Ling et al. (2025) studied this question.

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November 30, 2025Frontiers in EndocrinologyOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Study reveals protein carbonylation in β-cells contributes to dysfunction in type 1 and type 2 diabetes, highlighting oxidative stress implications.

Reduced functional β-cell mass is linked to oxidative stress and protein carbonylation in diabetes, and antioxidant enzymes may offer protection.
Increased lipid peroxidation and carbonylation observed in red blood cells and adipose tissue among patients with type 1 and type 2 diabetes.
Assessment of protein carbonylation's role in pancreatic islets suggests potential NRF2 activation benefits for β-cell preservation.
Understanding carbonylation's impact on β-cell function may inform approaches for better diabetes management.

Ling et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark