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November 30, 2025Molecular Systems BiologyOpen Access

Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD

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Authors

DMDezso ModosJTJohn P. ThomasJBJohanne Brooks-Warburton

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Overview

Systems genomics reveals distinct pathways in Crohn’s disease and ulcerative colitis, highlighting the challenges of non-coding SNPs in precision medicine.

Key Points

  • Non-coding SNPs stratify inflammatory bowel disease patients into distinct clusters, improving therapeutic response insights.
  • This approach models systems genomics, elucidating the role of signalling pathways in chronic immune-mediated disorders.
  • The analysis of 2,636 patient genomes identified novel pathogenic pathways associated with Crohn’s disease and ulcerative colitis.
  • Findings may enable better precision medicine strategies for complex diseases by addressing the challenges in SNP interpretation.

Cite This Study

Modos et al. (2025) studied this question.

synapsesocial.com/papers/692b94341d383f2b2a3786d7https://doi.org/10.1038/s44320-025-00169-3
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Also Consider

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  1. 1Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis2025
  2. 2Decoding the Molecular Landscape of Inflammatory Bowel Disease: A Mendelian Randomization and Machine Learning Analysis2025
  3. 3IBD GENETIC VARIATION CONTROLS T CELL EXPRESSION AND FUNCTION2026
  4. 4Phenome-wide association study of monogenic inflammatory bowel disease genes in diverse biobanks identifies population-specific and shared Goldilocks alleles: implications for Precision Medicine.2025
  5. 5Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease2025