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November 28, 2025Parasitology ResearchOpen Access

Comparative histopathological and immunological analysis of LRV2-positive and LRV2-negative Leishmania tropica in a BALB/c mouse cutaneous leishmaniasis model

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Authors

MÖMustafa ÖZTATLICIHOHulya OztatliciSASüha Kenan Arserim

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Overview

Comparative analysis of immune responses highlights oxidative stress in Leishmania tropica infections, impacting inflammation.

Key Points

  • Oxidative stress and inflammation were significant markers in Leishmania tropica infections in mice.
  • IL-6 levels were significantly elevated in both LRV2-positive and negative groups compared to controls.
  • Observational analysis utilized immunohistochemistry and qPCR to assess biomarkers and tissue responses.
  • The study indicates that while cytokine production remains unchanged, LRV2 enhances oxidative stress levels in tissues.

Cite This Study

ÖZTATLICI et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a3aahttps://doi.org/10.1007/s00436-025-08562-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The prevalence of Leishmania RNA virus in cutaneous leishmaniasis: a meta-analysis and systematic review2025
  2. 2Mice mucosal leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ T cell response2025 · 1 citations
  3. 3Histopathological and Heamatological Study in Experimentally Infected Rabbits with <i>Leishmania tropica.</i>2025
  4. 4First report of Leishmania RNA virus 2 and its high genetic diversity in cutaneous leishmaniasis cases from Ilam Province, Iran2025 · 1 citations
  5. 5BALB/c mice infection with hybrid Leishmania (V.) guyanensis/L. (V.) shawi showed an intermediate virulence profile compared to parental species infections2025