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November 28, 2025International Journal of SurgeryOpen Access

Enhanced diagnostic yield and clinical impact of metagenomic next-generation sequencing in infective endocarditis: a continuous and prospective surgical cohort study

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Authors

WWWei-Teng WangFCFanyu ChenLYLanxin Ye

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Overview

Prospective cohort study shows metagenomic sequencing enhances pathogen detection in infective endocarditis, suggesting significant impacts on clinical decision-making.

Key Points

  • mNGS enhances diagnostic performance, increasing sensitivity in blood culture-negative infective endocarditis.
  • AUC for mNGS reached 0.91, compared to 0.57 for tissue culture and 0.71 for blood culture.
  • Assessment of arterial blood and valve tissue confirmed the superiority of metagenomic sequencing in pathogen detection.
  • Improved diagnosis may lead to targeted therapy adjustments, mitigating potential false positives from traditional culture.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6928f113a65b730b9ea79e5dhttps://doi.org/10.1097/js9.0000000000003954
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