In vitro and in vivo findings reveal FTO's role in impaired autophagy and lipid accumulation in hepatic steatosis, suggesting a therapeutic target for metabolic disorders.
Key Points
Hepatic steatosis was improved with FTO knockdown, reducing lipid accumulation and enhancing autophagy.
In HepG2 cells, FTO demethylation resulted in notable changes in lipid metabolism and autophagy markers.
Assessed using in vitro and in vivo models, including fatty acids, dot blot, and Western blot analysis.
Findings highlight FTO's potential as a treatment target for hyperlipidemia and metabolic disorders.