Enhanced Risk Prediction for Coronary Heart Disease by Leveraging Polygenic Risk Score and Clinical Risk Score in European Hypertensive Adults

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Analysis finds integrating polygenic risk scores enhances coronary heart disease prediction, suggesting better risk assessment.

Adding the polygenic risk score significantly improved prediction of coronary heart disease, enhancing the C-index.
The top 20% of subjects showed a more than 3-fold likelihood of developing coronary heart disease, indicating strong association.
Using genome data from European ancestry, this observational study evaluated interactions in hypertensive populations.
Incorporating risk scores could lead to better identification of lifetime risk and effective intervention strategies.

Siyuan et al. (2025) studied this question.

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