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This research investigates the effects of Fh15 on pro-inflammatory cytokines and leukocyte infiltration in ulcerative colitis.

November 25, 2025The Journal of ImmunologyOpen Access

Recombinant Fasciola hepatica fatty acid binding protein (Fh15) reduces pro-inflammatory cytokines and modulates leukocyte infiltration in a DSS-induced ulcerative colitis mouse model 3681

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MFMaría Del Mar Figueroa-Gispert AAAlbersy Armina-Rodriguez COCarlimar Ocasio‐MalavéUniversity of Puerto Rico, Medical Sciences Campus

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Implication

Mouse model reveals Fh15 reduces pro-inflammatory cytokines and leukocyte infiltration in ulcerative colitis, suggesting helminth therapy could improve inflammation.

Key Points

This research investigates the effects of Fh15 on pro-inflammatory cytokines and leukocyte infiltration in ulcerative colitis.
C57BL/6 male mice were assigned to four groups (PBS, DSS, DSS-Fh15, Fh15).
Ulcerative colitis was induced using 4% DSS water for 7 days.
Fh15 was administered at 2.0 mg/kg intraperitoneally on days 1, 3, and 5.
qPCR assessed cytokine levels; immunohistochemistry quantified leukocyte staining.
Fh15 reduced pro-inflammatory cytokines TNFα and IL-1β in the distal colon.
Reduced serum myeloperoxidase levels were observed, indicating decreased neutrophil activity.
Fh15 significantly decreased macrophage and neutrophil infiltration in the colon.

Cite This Study

Figueroa-Gispert et al. (2025) studied this question.

synapsesocial.com/papers/692502be87af00ed34ac23ef https://doi.org/10.1093/jimmun/vkaf283.1452

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Implication

Mouse model reveals Fh15 reduces pro-inflammatory cytokines and leukocyte infiltration in ulcerative colitis, suggesting helminth therapy could improve inflammation.

Recombinant Fasciola hepatica fatty acid binding protein (Fh15) reduces pro-inflammatory cytokines and modulates leukocyte infiltration in a DSS-induced ulcerative colitis mouse model 3681

Discussion

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Implication

Key Points

Cite This Study

Recombinant Fasciola hepatica fatty acid binding protein (Fh15) reduces pro-inflammatory cytokines and modulates leukocyte infiltration in a DSS-induced ulcerative colitis mouse model 3681

Discussion

Member takes

Implication

Key Points

Cite This Study

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