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November 25, 2025The Journal of ImmunologyOpen Access

Molecular mechanisms of immunogenicity and TCR recognition of NRAS-derived public neoantigens 4770

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Authors

GPGihan PereraIEIñaki EtxeberriaCKChristopher Klebanoff

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Overview

Findings show distinct immunogenicity of NRAS-derived neoantigens, suggesting potential for cancer immunotherapies.

Key Points

  • This study aims to elucidate the molecular mechanisms and specificity of TCR recognition of NRAS-derived public neoantigens.
  • Used differential scanning fluorimetry to assess binding affinity to HLA-A*01:01.
  • Conducted X-ray crystallography to investigate structural differences between neoantigens and wild type (WT).
  • Employed surface plasmon resonance to analyze TCR specificity and affinity.
  • Neoantigens exhibit similar binding affinity to WT for HLA-A*01:01.
  • Distinct structural differences promote neoantigen-specific TCR interactions.
  • TCR specificity inversely correlates with affinity, indicating nuanced interactions.

Cite This Study

Perera et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac2046https://doi.org/10.1093/jimmun/vkaf283.2396
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