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November 4, 2025Current Neuropharmacology

Probiotics Decrease C-Reactive Protein Levels in Depression Depending on Metabolic Syndrome Presence or Antidepressant Treatment – Secondary Results of a Randomized Clinical Trial

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Authors

OGOliwia Gawlik-KotelnickaAWAdam WysokińskiAGAgata Gajewska

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Overview

Randomized clinical trial shows probiotics decrease C-reactive protein in depression, indicating metabolic syndrome may modify treatment effects.

Key Points

  • Probiotic supplementation decreased C-reactive protein levels by 21.3% in patients with depression and metabolic syndrome.
  • In a double-blind, controlled trial, 88 participants were analyzed over 60 days for changes in inflammatory parameters.
  • The effect of probiotics differed based on baseline metabolic syndrome presence and antidepressant use.
  • This study highlights the potential of probiotics as an adjunctive treatment option for depression and related inflammatory conditions.

Cite This Study

Gawlik-Kotelnicka et al. (2025) studied this question.

synapsesocial.com/papers/690945348f2297dc13532fc5https://doi.org/10.2174/011570159x371175251002220658
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