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October 31, 2025Exploration of MedicineOpen Access

Reduced versus standard dose craniospinal irradiation with chemotherapy to treat medulloblastoma

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Authors

IHIyawnna HazzardMGMarina M GeorgiesMBM. Bali

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Overview

Systematic review shows low-dose craniospinal irradiation improves cognitive function in medulloblastoma patients while maintaining survival rates.

Key Points

  • Low-dose craniospinal irradiation associated with improved cognitive outcomes compared to standard-dose.
  • Five-year event-free survival achieved ranged from 27.3% to 83% across analyzed studies.
  • Systematic review conducted following PRISMA guidelines analyzed 749 studies, including 24 that met inclusion criteria.
  • Highlights importance of adapting treatment based on histological features and molecular subgroups.

Cite This Study

Hazzard et al. (2025) studied this question.

synapsesocial.com/papers/6903fee5b25c631a4265ff32https://doi.org/10.37349/emed.2025.1001366
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