Phytochemical screening shows Moringa oleifera root extracts exhibit anti-cholesterol effects and antimicrobial activity against Escherichia coli.
Moringa (Moringa oleifera) is a plant that contains active ingredients as a result of secondary metabolism that can be utilized as traditional medicine. Moringa oleifera (MO) can overcome various diseases, such as diabetes, gout, and cancer. This study aimed to evaluate the influence of methanol concentration and acid addition on the anti-cholesterol activity and secondary metabolite profile of Moringa oleifera root extract (EMr). As well as knowing the content of secondary metabolite compounds from the EMr of MO roots. The research methods included maceration extraction, phytochemical screening, yield test, LCMS/MS analysis, Escherichia coli antibacterial test, and anticholesterol test on mice. Data were analyzed with SPSS (version 24) using the ANOVA test followed by the Tukey test. The results showed that the concentration of methanol solvent by adding acid (MO4) significantly retardation of Escherichia coli growth at 6% concentration with a Minimum Inhibitory Concentration (MIC) of 19 mm (p<0.05) and demonstrated greater efficacy compared to MO1, MO2, MO3, MO5, and MO6. Phytochemical screening indicated that it contains flavonoid, alkaloid, and terpenoid compounds and the results of LCMS/MS analysis obtained 21 verified compounds. The results showed that MO root EM has anti-cholesterol activity at 400 mg doses (p<0.05).
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Ahsan et al. (2025) studied this question.