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October 27, 2025International Journal of Diabetes and Technology

Clinical Assessment of Large Language Models: A Comprehensive Multi-domain Performance Study for Healthcare Applications

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Authors

HHHarsh HiraniBSBharat SabooAMAlok Modi

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Overview

Comprehensive evaluation shows Perplexity leads in safety metrics, indicating variances among LLM applications in healthcare.

Key Points

  • Significant performance variations were revealed among large language models in healthcare applications.
  • Perplexity emerged as the top model for safety, achieving 94% accuracy in source citations while exposing critical safety concerns.
  • Evaluation framework assessed four models across 15 clinical domains using standardized testing scenarios to mimic real-world applications.
  • Current models need rigorous safety protocols and multi-platform strategies for effective clinical integration.

Cite This Study

Hirani et al. (2025) studied this question.

synapsesocial.com/papers/68ff87d8c8c50a61f2bdcc67https://doi.org/10.4103/ijdt.ijdt_31_25
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