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October 23, 2025Breast Cancer ResearchOpen Access

Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence

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Authors

IPIn Ho ParkSSSu‐Jin ShinHGHeounjeong Go

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Overview

Spatial analysis reveals immunosuppressive tumor microenvironment in triple-negative breast cancer post-neoadjuvant chemotherapy, suggesting tumor-infiltrating lymphocytes may help tailor therapy.

Key Points

  • Patients achieving pathologic complete response show stronger immune responses, emphasizing the role of tumor-infiltrating lymphocytes.
  • Analysis of biopsy tissue slides from 16 patients identifies significant differences in immune cell composition.
  • Multiplex immunofluorescence technique utilized to study immune cell interactions in the tumor immune microenvironment.
  • Findings may optimize neoadjuvant chemotherapy outcomes through targeted immune-based biomarkers.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f742160https://doi.org/10.1186/s13058-025-02132-4
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  1. 1American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer2010 · 4,301 citations