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Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial on the efficacy and safety of PMSoff

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Randomized trial demonstrated PMSoff improved premenstrual syndrome symptoms in women, indicating potential as an alternative treatment.

PMSoff significantly reduced PMS symptoms after two months of treatment, as measured by the Daily Record of Severity of Problems (DRSP).
Of the 218 women enrolled, adherence to medication was reported at 72% during the initial treatment months.
This randomized double-blind clinical trial evaluated the natural supplement PMSoff against a placebo on symptom severity and safety.
Findings support PMSoff's potential as a natural alternative or adjunct to standard pharmacological treatments for PMS and PMDD.

Saghafi et al. (2025) studied this question.

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View Full Paper

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Authors

Randomized trial demonstrated PMSoff improved premenstrual syndrome symptoms in women, indicating potential as an alternative treatment.

PMSoff significantly reduced PMS symptoms after two months of treatment, as measured by the Daily Record of Severity of Problems (DRSP).
Of the 218 women enrolled, adherence to medication was reported at 72% during the initial treatment months.
This randomized double-blind clinical trial evaluated the natural supplement PMSoff against a placebo on symptom severity and safety.
Findings support PMSoff's potential as a natural alternative or adjunct to standard pharmacological treatments for PMS and PMDD.

Saghafi et al. (2025) studied this question.

View Full Paper

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