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October 23, 2025Cancer Cell InternationalOpen Access

NR2F6 regulates Temozolomide resistance in glioma via the E2F2-PARP1 pathway

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Authors

BWBo WangPXPengfei XueRLRongrong Li

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Overview

Observational analysis identified NR2F6's role in drug resistance and DNA damage repair in glioblastoma, suggesting novel therapeutic strategies are needed.

Key Points

  • Temozolomide resistance decreased sensitivity in glioma cells, leading to higher drug resistance rates.
  • E2F2 and PARP1 upregulation was noted in 648 glioma samples from TCGA and in 325 samples from CGGA.
  • Analysis was performed using RNA sequencing data and statistical analyses with R language and GraphPad Prism.
  • Highlighting the significant implications of NR2F6 for improving patient prognosis and chemotherapeutic strategies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f7420c4https://doi.org/10.1186/s12935-025-03986-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated expression and secretion of TGF-α contribute to Temozolomide resistance in human glioblastoma cells2025 · 2 citations
  2. 2Co-activation of the super-enhancer complex SOX2 and HDAC1 confers temozolomide resistance by promoting PDGFB transcription in glioblastoma2025 · 5 citations
  3. 3N 6 -methyladenosine promotes temozolomide resistance through mRNA stabilization in glioblastoma cells2025
  4. 4Targeting TBC1D15 Reverses TMZ-resistance in Glioblastoma by Modulating Lysosomal Ca²⁺/TFEB/Cx43 Axis via Mitochondria-Lysosome Contact2025
  5. 5The HBP Pathway Inhibitor FR054 Enhances Temozolomide Sensitivity in Glioblastoma Cells by Promoting Ferroptosis and Inhibiting O‐ GlcNAcylation2025 · 7 citations