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October 23, 2025AIDS Research and TherapyOpen Access

Ten-year outcomes of antiretroviral therapy: a retrospective cohort study in Tshwane district, South Africa

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Authors

KMKateko MhlongoMLMurray LouwSNSanele Ngcobo

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Overview

Retrospective cohort study reports 10-year retention of 47.7% in HIV patients, indicating significant mortality and loss to follow-up challenges.

Key Points

  • Fewer than half of HIV patients remained in care after 10 years, with a mortality rate indicating high-risk groups.
  • At 10 years, we noted 30.4% loss to follow-up and 3.3% mortality among participants with advanced disease.
  • Analysis utilized Kaplan-Meier methods for retention and Cox models for mortality across 1,337 HIV patients.
  • Differentiated service delivery could improve treatment outcomes and retention rates for HIV care in South Africa.

Cite This Study

Mhlongo et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f7420a7https://doi.org/10.1186/s12981-025-00814-9
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