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October 23, 2025CancersOpen Access

The Impact of Local Ablative Therapies as Bridging Treatment on Overall Survival Following Liver Transplantation in Patients with HCC

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Authors

LSLaura SchwenkFDFelix DondorfOROliver Rohland

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Overview

Retrospective analysis shows neoadjuvant therapies improve overall survival in liver transplantation for hepatocellular carcinoma, suggesting tailored approaches may be needed.

Key Points

  • Overall survival rates post-liver transplantation were significantly higher for patients who received neoadjuvant therapies.
  • Among 107 patients, 90 received neoadjuvant therapy, yielding 1-, 3-, and 5-year OS rates of 93.5%, 82.2%, and 79.4%, respectively.
  • Retrospective analysis evaluated patients undergoing living donor liver transplantation at Jena University Hospital from 2019 to 2023, examining treatment impacts.
  • Findings suggest that tailored neoadjuvant therapies may optimize outcomes based on tumor burden and transplantation criteria.

Cite This Study

Schwenk et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3d8dhttps://doi.org/10.3390/cancers17203393
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of radiological interventions in hepatocellular carcinoma before liver transplantation: a surgical perspective2025
  2. 2Management of hepatocellular carcinoma prior to liver transplantation: latest developments2025 · 4 citations
  3. 3Pathological study of the tumor microenvironment after neoadjuvant therapy in hepatocellular carcinoma: Difference of TACE combined with antiangiogenics and immunotherapy2025
  4. 4Impact of Surgical Resection on Hepatocellular Carcinoma Following Systemic Drug Therapy: A Multicenter Retrospective Observational Study2025
  5. 5Review Article: Liver Transplantation for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors.2025 · 1 citations